Researchers at AACR described the development of a classifier that identified a proportion of tumor samples with HRD that did not have BRCA1/2 mutations.

Genomic instability is a defining hallmark of cancer, underpinning tumor initiation, evolution, and progression. Increasingly, genomic instability itself is recognized not merely as a consequence of ...

USC Dornsife researchers discover that “condensates” formed by the protein Nup98 help cells avoid catastrophic errors when repairing breaks in tightly packed DNA, a finding with implications for ...

DNADX high scores predicted improved PFS, supporting genomic instability and DNA repair deficiency as biologically relevant determinants of sensitivity to deruxtecan’s topoisomerase I inhibitor ...

Genome instability is the main risk factor in the development of tumors in humans. Understanding how, where, when and why these mutations are produced in DNA is one of the great objectives of the ...

A multi-lab team led by Gladstone Institutes has successfully adapted retron-based genome editing—previously limited to E. coli—for use in 14 additional bacterial species across three major branches ...

Integrating circulating tumor DNA (ctDNA) and TP53 alteration variant allele frequency (VAF) to predict outcomes in advanced urothelial carcinoma (aUC) treated with enfortumab vedotin (EV).

Scientists from Skoltech and the University of Potsdam have developed a physical theory that sheds light on how molecular ...

Powered by gene editing advances like CRISPR and base editing, cell and gene therapy (CGT) is delivering on the promise of genomic medicine. First-generation CAR T-cell therapies, for example, have ...