Researchers developed a computer simulation that rapidly and accurately predicts how proteins shift their shapes, potentially advancing drug design and protein engineering.

For many people, "protein" is the key element of a food order. However, beyond the preferred choice of meats or plant-based ...

Liquid-liquid phase separation is not a precursor to formation of amyloid fibrils, a pathological hallmark of Parkinson's disease, shows study. Rather, the formation of protein into liquid droplets ...

Neurodegenerative diseases, such as Alzheimer's disease and dementia, are medical conditions that entail the progressive loss of neurons and a decline in brain function. Past studies have found a link ...

Raghu R. Chivukula, MD, Ph.D., a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is ...

Protein-based therapeutics have transformed treatments for numerous diseases, yet their production remains highly complex and cost-intensive [1][2],[3][4]. Downstream processing (DSP), including ...

PTIR calculates the rates at which originally monomeric proteins are transformed into aggregates at various temperatures under initial-rate settings. Utilizing SMSLS for identical conditions generates ...

Proteins often function in pairs or groups, concealing their internal connection points and making it difficult for scientists to study their individual units without altering their natural structure.

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In patients with Huntington’s disease, proteins misfold and clump together. Researchers imagine the treatment could potentially someday be administered as a once-weekly injection to delay disease ...