Resistant and severe hypertension represent a growing global health burden and are associated with a markedly increased risk of cardiovascular, renal, and ...

Aldosterone synthase (CYP11B2) is the key enzyme responsible for the final steps in aldosterone production, a steroid hormone that plays a critical role in the regulation of electrolyte balance and ...

Lorundrostat, a novel therapy which blocks the production of aldosterone from the adrenal glands, demonstrated clinically meaningful and sustained reductions in blood pressure in 1,083 patients with ...